The Chaenomeles sinensis fruit is used as an effective antitussive agent, analgesic, and diuretic\nin traditional Chinese medicine. It has been reported that C. sinensis fruit extracts have antimicrobial\nand anti-inflammatory effects. However, there are very few reports about the effects of C. sinensis\nextracts on skin. In this study, we investigated the effect of C. sinensis extracts on skin aging. The\nresults of in vitro assays showed that whole fruit extracts of C. sinensis had superoxide dismutase\n(SOD)-like activity and inhibited the activity of dermal extracellular matrix proteases: Elastase and\ncollagenase. The inhibitory effect of the whole fruit (containing seeds) extract on elastase activity\nwas higher than that of the sarcocarp (seeds removed) extract. Further, the sarcocarp extract showed\na higher level of SOD-like activity and a greater inhibitory effect on collagenase activity than the\nwhole fruit extract. In particular, among the three activities studied, the sarcocarp extract showed the\nmost significant inhibitory effect on collagenase activity at low concentrations. The polyphenol-rich\nfraction obtained from the sarcocarp showed significant collagenase inhibition. Based on these results,\nwe concluded that phenolic compounds from C. sinensis sarcocarp have the potential to protect\nagainst skin aging through anti-collagenase activity...............
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